CATDOLL : CATDOLL: What are the main ingredients of Biejia Jianwan? What are its uses?

[Source] Volume 1 of "Golden Chamber Essentials"

[Other name] Malaria Decoction

〖Composition〗Turtle shell 12 fen (roasted), black fan 3 fen (blasted), scutellaria 3 fen, bupleurum 6 fen, wood louse 3 fen (boiled), dried ginger 3 fen, rhubarb 3 fen, peony 5 fen, cassia twig 3 fen, scutellaria 1 fen (boiled), stone reed 3 fen (dehaired), Magnolia officinalis 3 fen, peony 5 fen (de-cored), superbus 2 fen, purple trumpetwort 3 fen, pinellia 1 fen, ginseng 1 fen, (common insect) 5 fen (boiled), donkey-hide gelatin 3 fen (roasted), beehive 4 fen (roasted), red saltpeter 12 fen, dung beetle 6 fen (boiled), peach kernel 2 fen.

[Usage] Grind the above 23 herbs into powder, take 1 dou of ash from the calcined stove, 1 hu and 5 dou of rice wine, soak the ash, and wait until half of the wine is gone. Put the turtle shell in it, boil it until it is as soft as glue, squeeze out the juice, add other herbs, and boil it into pills as big as walnuts. Take seven pills on an empty stomach, three times a day. [Modern usage: Take 3 jin of ash from the stove, 10 jin of rice wine, soak the ash, filter out the juice, boil the turtle shell until it is gelatinous, and grind the other 22 herbs into fine powder. Put the turtle shell glue into refined honey, mix well and make small pills. Take 3g each time, three times a day.]

[Function] Eliminate stagnation, promote blood circulation, remove blood stasis, soothe the liver and relieve depression

[Formula] Activate blood circulation and dissipate blood stasis with turtle shell decoction, honeycomb, dung beetle, scutellaria, cinnamon bark, ginseng, summer turmeric, scutellaria, peony root, etc. Add stone reed, glue, and wheat bark. If the mother of malaria has blood stasis in the flank for a long time, it will cause abdominal pain, weight loss, and stop the menstruation of women. Take it to dissipate phlegm and soften the hard masses.

〖use〗

1. This prescription is a famous prescription for eliminating symptoms and removing lumps. The key points of diagnosis and treatment are the lumps under the hypochondrium, pain when touched, inability to move when pushed, dull tongue, and stringy and thin pulse.

2. It is commonly used to treat liver cirrhosis, hepatosplenomegaly, liver cancer and other diseases that meet the above-mentioned diagnosis and treatment points.

3. It can also be used for jaundice caused by blood stasis and liver depression.

[Usage] Since this prescription is good at dispersing masses, it is not strong enough to strengthen the body. Therefore, it should be used with caution in patients with masses and severe deficiency of vital energy.

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Version 1

【Drug name】Biejia Jianwan[1]

[Main ingredients] Turtle shell glue, donkey-hide gelatin, beehive, woodlice, earthworm, dung beetle, saltpeter, bupleurum, scutellaria, pinellia, codonopsis, dried ginger, magnolia bark, cassia twig, white peony root, belamcanda chinensis, peach kernel, peony bark, rhubarb, trumpet creeper, scutellaria baicalensis, pyrrosia, and superbus.

【Pharmacological action】

1. Anti-liver fibrosis effect

1.1 The turtle shell, earthworm and peach kernel in this medicine can inhibit the proliferation of connective tissue. The turtle shell is rich in protein, amino acids and trace elements, so it can increase plasma protein.

1.2 Experimental study on anti-liver fibrosis Serum PC-Ⅲ content can reflect the activity level and degree of liver fibrosis, and is one of the important markers for diagnosing liver fibrosis. It also reflects the inflammation and necrosis of liver cells. HA is an important indicator of the degree of liver fibrosis in chronic liver disease. Serum LN increases significantly in chronic active hepatitis and cirrhosis, and can reflect the severity of liver fibrosis. Increased synthesis of Ⅳ-C is one of the early manifestations of liver fibrosis. In the experiment of Li Xuebin using pig serum intraperitoneal injection to induce liver fibrosis in rats, the control group of Biejia Jianwan had a reduced PC-Ⅲ, HA, LN, and Ⅳ-C, indicating that Biejia Jianwan has an inhibitory effect on liver fibrosis and is an ideal drug for the clinical treatment of chronic liver disease. Xie Shiping et al. observed the effect of Biejiajianwan on the expression of collagen and related cytokines in liver tissue of rats with immune fibrosis model. Using the immune liver fibrosis rat model, in situ hybridization was used to detect TGF-β1mRNA in liver tissue, and immunohistochemistry was used to detect type I and III collagen and platelet-derived growth factor (PDGF-BB), fibroblast growth factor (bFGF), and colchicine was used as a control. The experimental results showed that Biejiajianwan can effectively reduce the production of type I and III collagen, and can significantly inhibit the expression of TGF-β1mRNA and cytokines such as PDGF-BB and bFGF. The expression of these cytokines is positively correlated with the expression of type I and III collagen, suggesting that Biejiajianwan can reduce the synthesis of ECM such as type I and III collagen by HSC by inhibiting the expression of TGF-β1, PDGF-BB and bFGF cytokines, thereby playing a role in preventing and treating liver fibrosis. He Songqi et al. established a rat model of liver fibrosis with complex factors, and used immunohistochemistry to observe the effect of Biejia Jianwan on the expression of connective tissue growth factor (CTGF) in the liver tissue of rats with liver fibrosis. The experimental results showed that Biejia Jianwan could significantly reduce the collagen fiber deposition and pseudolobule structure of the model rats, and effectively inhibit the expression of CTGF in liver fibrosis tissue, which was significantly different from the model group (P < 0.01). It suggests that Biejia Jianwan can effectively treat rat liver fibrosis induced by complex factors, and its mechanism of action may be to inhibit the expression of CTGF in liver fibrosis tissue and then block the effect of TGF-β1 on promoting collagen synthesis, inhibit the synthesis of extracellular matrix (ECM), and finally delay the process of liver fibrosis. In an experiment conducted by Xie Shiping et al. to study the effect of Biejia Jianwan on the expression of TNF-α in rats with immune liver fibrosis, pig serum was used to induce an immune-damaging liver fibrosis model, and immunohistochemistry was used to detect the TNF-α content in the liver tissue of the model rats. The results showed that the expression of TNF-α in the liver of the liver fibrosis model rats was significantly increased, and Biejia Jianwan could significantly inhibit the expression of TNF-α and inhibit the pathological changes of liver fibrosis, suggesting that Biejia Jianwan may play an anti-liver fibrosis role by inhibiting the expression of TNF-α, blocking or weakening its biological effects, inducing HSC apoptosis, and thereby regulating the generation and degradation of ECM.

2. Immunomodulatory effect Turtle shell can enhance humoral immune function, while peach kernel, moutan bark, etc. can inhibit cellular immune function. Therefore, this medicine has a certain regulatory effect on the immune dysfunction of patients with liver disease.

3. Experimental study on the treatment of renal interstitial fibrosis Han Lin et al. studied the protective effect of Biejia Jianwan on the kidneys of rats with renal interstitial fibrosis model. They used unilateral ureteral ligation to replicate the rat renal obstruction model and randomly divided the rats into valsartan group, Biejia Jianwan group and model group, and set up a sham operation group. The expression of adrenomedullin (ADM) at the protein and gene levels in the obstructed kidney was observed, and its protein content in renal tissue was determined. The results showed that Biejia Jianwan could increase the content of ADM in renal tissue and upregulate the expression of adrenomedullin at the protein and gene levels, which may be one of the possible mechanisms of Biejia Jianwan in the treatment of renal diseases. Fan Huanfang et al. selected three healthy adult volunteers of similar age and weight to prepare the drug serum of Biejia Jianwan. Using lipopolysaccharide (LPS) as a stimulating factor, the MTT method was used to detect the proliferation of mesangial cells, and the enzyme-linked immunosorbent assay (ELISA) method was used to detect the content of laminin (LN) and type IV collagen (Col-Ⅳ) in ECM. The experimental results showed that Biejia Jianwan and valsartan drug serum could significantly inhibit the secretion of LN and Col-Ⅳ of mesangial cells under normal culture conditions and LPS stimulation conditions. In terms of inhibiting the secretion of LN and Col-Ⅳ, Biejia Jianwan drug serum is superior to valsartan drug serum. This proves that Biejia Jianwan has significant effects in preventing and treating chronic kidney disease, inhibiting the proliferation of mesangial cells, and reducing the accumulation of extracellular matrix ECM.

4. Experimental study on anti-tumor effects Zhang Xuhui et al. used H22 tumor-bearing mice as subjects and cyclophosphamide as a positive control drug to observe the inhibitory effect of Biejia Jianwan on tumor masses. The results showed that the tumor inhibition rates of the high-dose Biejia Jianwan group and the low-dose Biejia Jianwan group were significantly different from those of the negative control group (P<0.01); there was no significant difference in the tumor inhibition rate between the high-dose Biejia Jianwan group and the cyclophosphamide group (P>0.05). The results showed that Biejia Jianwan could significantly inhibit tumor growth, and its effect was similar to that of cyclophosphamide. In the experiment of studying the anti-tumor effect of Biejia Jianwan on tumor-bearing mice and its effect on thymus index and spleen index, Chen Dali et al. set up high-dose and low-dose groups of Biejia Jianwan, and administered the medicine to H22 tumor-bearing mice by gavage for 15 consecutive days. The tumor inhibition rate and thymus index and spleen index were measured, and compared with the cyclophosphamide group. The tumor inhibition rate of the high-dose group of Biejia Jianwan reached 31.8%, and the tumor weight after treatment was significantly lower than that of the negative control group. The body weight, thymus index and spleen index were significantly better than those of the cyclophosphamide group, indicating that Biejia Jianwan can not only inhibit tumor growth, but also protect the thymus and spleen.

【Clinical Application】

1. This drug can reduce the concentration of zinc sulfate and thymol, correct the abnormal A/G ratio, promote liver and spleen retraction, and improve liver function after treating chronic hepatitis and cirrhosis.

2. Liver cancer can improve symptoms and prolong survival.

【Function】Activate blood circulation and dissipate blood stasis, soften and disperse lumps. Suitable for treating lumps under the ribs.

[Usage and Dosage] Oral administration. Take 2 large honey pills each time, 6g small honey pills each time, and 3g water honey pills each time, 2-3 times a day with warm water.

【Precautions】Pregnant women should not take. Store in a sealed and dry place.

【Approval number】National Medicine Standard Z42020772

【Manufacturer】Wuhan Zhonglian Pharmaceutical Group Co., Ltd.

Version 2

Biejia Jianwan

[Drug composition] Turtle shell 2 liang (pounded into powder separately), dry lacquer (pounded and fried until smoke comes out) 1 liang, aconite (cracked and peeled with navel removed) 1 liang, Jing Sanleng 1 liang (cracked and filed), Sichuan rhubarb 1 liang (filed and fried), costus root half a liang.

[Prescription source] Volume 28 of "Shenghui".

[Prescription indications] Consumption and persistent lumps in the lungs.

[Contraindications] Avoid eating amaranth and raw or cold food.

[Usage and Dosage] Grind the above ingredients into powder. First, boil the turtle shell powder with 3 liters of vinegar until it becomes thick, then add the powder of other herbs to make pills as big as sycamore seeds. Take 10 pills each time, on an empty stomach or before dinner, with warm wine.

【Notes】

Pregnant women should not take it. Store tightly closed in a dry place.

[Fang Yuan]

Volume 1 of "Golden Chamber Essentials"

[Other name] Malaria Decoction

〖Composition〗Turtle shell 12 fen (roasted), black fan 3 fen (blasted), scutellaria 3 fen, bupleurum 6 fen, wood louse 3 fen (boiled), dried ginger 3 fen, rhubarb 3 fen, peony 5 fen, cassia twig 3 fen, scutellaria 1 fen (boiled), stone reed 3 fen (dehaired), Magnolia officinalis 3 fen, peony 5 fen (de-cored), superbus 2 fen, purple trumpet 3 fen, pinellia 1 fen, ginseng 1 fen, (common insect) 5 fen (boiled), donkey-hide gelatin 3 fen (roasted), beehive 4 fen (roasted), red saltpeter 12 fen, dung beetle 6 fen (boiled), peach kernel 2 fen.

〖usage〗

Grind the above 23 herbs into powder, take 1 dou of ash from the calcined stove, 1 hu and 5 dou of rice wine, soak the ash, wait until half of the wine is gone. Put the turtle shell in it, boil it until it is as soft as glue, squeeze out the juice, add other herbs, boil it into pills, as big as walnuts, take seven pills on an empty stomach, three times a day. [Modern usage: take 3 jin of ash from the stove, 10 jin of rice wine, soak the ash, filter out the juice, boil the turtle shell until it is gelatinous, grind the other 22 herbs into fine powder, put the turtle shell glue into refined honey, mix well to make small pills, take 3g each time, three times a day.]

〖function〗

Eliminate abdominal distension and resolve accumulation

Activate blood circulation and remove blood stasis

Soothe the liver and relieve depression

[Formula] Activate blood circulation and dissipate stasis with turtle shell decoction, honeycomb, dung beetle, scutellaria, cinnamon bark, ginseng, summer turmeric, scutellaria, peony root, etc. Add stone reed, glue, and wheat bark. If the malaria mother has been in the flank for a long time, it will cause abdominal pain, weight loss, and stop the menstruation of women. Take it to dissipate phlegm and soften the hard masses.

〖use〗

1. This prescription is a famous prescription for eliminating symptoms and removing lumps. The key points of diagnosis and treatment are the lumps under the hypochondrium, pain when touched, inability to move when pushed, dull tongue, and stringy and thin pulse.

2. It is commonly used to treat diseases such as cirrhosis, hepatosplenomegaly, liver cancer, etc., which meet the above-mentioned diagnosis and treatment points.

3. It can also be used for jaundice caused by blood stasis and liver depression.

[Usage] Since this prescription is good at dispersing masses, it is not strong enough to strengthen the body. Therefore, it should be used with caution in patients with masses and severe deficiency of vital energy.

Edit this paragraph using comments

Version 1

【Drug name】Biejia Jianwan

[1]

[Main ingredients] Turtle shell glue, donkey-hide gelatin, beehive, woodlice, earthworm, dung beetle, saltpeter, bupleurum, scutellaria, pinellia, codonopsis, dried ginger, magnolia bark, cassia twig, white peony root, belamcanda chinensis, peach kernel, peony bark, rhubarb, trumpet creeper, scutellaria baicalensis, pyrrosia, and superbus.

【Pharmacological action】

1. Anti-liver fibrosis effect

1.1 The turtle shell, earthworm and peach kernel in this medicine can inhibit the proliferation of connective tissue. The turtle shell is rich in protein, amino acids and trace elements, so it can increase plasma protein.

1.2 Experimental study on anti-liver fibrosis The serum PC-Ⅲ content can reflect the activity level and degree of liver fibrosis, and is one of the important markers for diagnosing liver fibrosis. It also reflects the inflammation and necrosis of liver cells. HA is an important indicator reflecting the degree of liver fibrosis in chronic liver disease. Serum LN increases significantly in chronic active hepatitis and cirrhosis, and can reflect the severity of liver fibrosis. Increased synthesis of Ⅳ-C is one of the early manifestations of liver fibrosis. In Li Xuebin's experiment on rat liver fibrosis caused by intraperitoneal injection of pig serum, the control group Biejia Jianwan had reduced PC-Ⅲ, HA, LN, and Ⅳ-C, indicating that Biejia Jianwan has an inhibitory effect on liver fibrosis and is an ideal agent for the clinical treatment of chronic liver disease. Xie Shiping et al. observed the effect of Biejia Jianwan on the expression of collagen and related cytokines in liver tissue of rats with immune fibrosis model.

Using the immune liver fibrosis rat model, the TGF-β1mRNA in the liver tissue was detected by in situ hybridization, and the type I and III collagens, platelet-derived growth factor (PDGF-BB), and fibroblast growth factor (bFGF) were detected by immunohistochemistry. The western medicine colchicine was used as a control. The experimental results showed that Biejia Jianwan can effectively reduce the production of type I and III collagens, and can significantly inhibit the expression of TGF-β1mRNA and cytokines such as PDGF-BB and bFGF. The expression of these cytokines is positively correlated with the expression of type I and III collagens, suggesting that Biejia Jianwan can reduce the synthesis of ECM such as type I and III collagen by HSC by inhibiting the expression of TGF-β1, PDGF-BB, and bFGF cytokines, thereby playing a role in preventing and treating liver fibrosis.

He Songqi et al. used a complex factor to establish a rat model of liver fibrosis, and used immunohistochemistry to observe the effect of Biejia Jianwan on the expression of connective tissue growth factor (CTGF) in the liver tissue of rats with liver fibrosis. The experimental results showed that Biejia Jianwan could significantly reduce the collagen fiber deposition in the model rats, significantly reduce the pseudolobular structure, and effectively inhibit the expression of CTGF in liver fibrosis tissue, with significant differences compared with the model group.

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